Toll-Like Receptors and Skin Cancer
نویسندگان
چکیده
The skin, the largest organ in the body, provides the first line of defense against the environment both as a physical barrier and as a key immunological component. Toll-like receptors (TLRs) serve as signaling molecules that recognize pathogenassociated molecular patterns (PAMPs) as well as damage-associated molecular patterns (DAMPs), and are expressed by various skin cells including keratinocytes and melanocytes, which are the main cell types involved in both non-melanoma and melanoma skin cancers. TLRs induce inflammatory responses meant for clearing pathogens, but can ultimately contribute to skin carcinogenesis. In contrast, TLR agonists, specifically targeting TLR7, 8, and 9, have been successfully used as therapeutics for melanoma and basal cell carcinoma (BCC), functioning by recruiting dendritic cells and inducing T-cell responses. Here, we discuss the role TLRs play in skin carcinogenesis as well as the use of TLRs as targets for skin cancer treatment options.
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